@prefix jvr: . @prefix skos: . @prefix mesh: . @prefix dc: . @prefix xsd: . @prefix owl: . jvr:-B1C9KKFQ-T skos:broader jvr:-NZM93WB5-8 ; mesh:allowableQualifier jvr:-R3QWLHRG-V, jvr:-HQRFT0C6-B, jvr:-CJXMKG5Q-F, jvr:-Q3979798-W, jvr:-G30ZJ446-J, jvr:-XV06LPML-W, jvr:-FWD2BGQ0-9, jvr:-D0F21513-5, jvr:-CB30NGKB-3, jvr:-TJHVZCRZ-0, jvr:-L6C0XPHT-4, jvr:-SBNWSM1T-R, jvr:-W6SQV79N-S, jvr:-NKM836P1-M, jvr:-H7K65Q8S-Z, jvr:-N2WP45CN-V, jvr:-S0CS1X5R-5, jvr:-Z9TSGBXH-4, jvr:-G7KXQWSR-5, jvr:-THHNVC7V-3, jvr:-T2TS0S41-N, jvr:-NHL3D2X0-S, jvr:-BT300B3G-Q, jvr:-NB0XHT3S-N, jvr:-T9HQD7ST-J, jvr:-M63HSDM7-1, jvr:-NFTHND7Q-8, jvr:-WZF2ZR3L-B, jvr:-WK5F724J-1 ; a mesh:Descriptor, skos:Concept ; skos:altLabel "P42 MAPK"@fr, "MAP-kinase-p42"@fr, "Protéine-kinase-p42 activée par les mitogènes"@fr, "P42 mitogen-activated protein kinase"@fr, "p42(Mapk) Kinase"@en, "MAPK2 Mitogen-Activated Protein Kinase"@en, "p42(Mapk)"@en, "p42 MAP Kinase"@en, "p42 MAPK"@en, "Protéine-kinase-1 activée par les facteurs mitogènes"@fr, "Protein-kinase Mk1"@fr, "Kinase-2 régulée par un signal extracellulaire"@fr, "ERK-2"@fr, "MAP Kinase 2"@en, "Mitogen-Activated Protein Kinase 2"@en, "Extracellular Signal-Regulated Kinase 2"@fr, "Extracellular Signal-Regulated Kinase 2"@en, "p42(Mitogen-activated protein kinase)"@fr, "MAP-kinase-2"@fr, "Protéine-kinase-2 activée par les facteurs mitogènes"@fr, "MAPK1 Mitogen-activated protein kinase"@fr, "Protéine-kinase-2 régulée par des signaux extracellulaires"@fr, "Protéine-kinase-1 activée par les agents mitogènes"@fr, "MAPK1 Mitogen-Activated Protein Kinase"@en, "p42(Mitogen-Activated Protein Kinase)"@en, "MAPK2 Mitogen-activated protein kinase"@fr, "ERK2"@fr ; skos:prefLabel "Mitogen-Activated Protein Kinase 1"@fr, "Mitogen-Activated Protein Kinase 1"@en ; dc:modified "2021-05-21"^^xsd:date ; mesh:registryNumber "EC 2.7.11.24" ; owl:sameAs ; dc:created "1997-07-02"^^xsd:date ; skos:definition "A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms."@en ; skos:hiddenLabel "EC 2.7.11.24"@fr, "EC 2.7.11.24"@en ; skos:inScheme jvr: ; dc:established "1998-01-01"^^xsd:date . jvr:-BT300B3G-Q skos:prefLabel "cerebrospinal fluid (Qualifier)"@en, "liquide cérébrospinal (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-L6C0XPHT-4 skos:prefLabel "métabolisme (Qualificatif)"@fr, "metabolism (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-XV06LPML-W skos:prefLabel "urine (Qualifier)"@en, "urine (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NZM93WB5-8 skos:prefLabel "Extracellular Signal-Regulated MAP Kinases"@fr, "Extracellular Signal-Regulated MAP Kinases"@en ; a mesh:Descriptor, skos:Concept ; skos:narrower jvr:-B1C9KKFQ-T . jvr:-G7KXQWSR-5 skos:prefLabel "biosynthèse (Qualificatif)"@fr, "biosynthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Z9TSGBXH-4 skos:prefLabel "génétique (Qualificatif)"@fr, "genetics (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-Q3979798-W skos:prefLabel "analysis (Qualifier)"@en, "analyse (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-H7K65Q8S-Z skos:prefLabel "radiation effects (Qualifier)"@en, "effets des radiations (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-TJHVZCRZ-0 skos:prefLabel "administration et posologie (Qualificatif)"@fr, "administration & dosage (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-G30ZJ446-J skos:prefLabel "toxicity (Qualifier)"@en, "toxicité (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NFTHND7Q-8 skos:prefLabel "intoxication (Qualificatif)"@fr, "poisoning (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-FWD2BGQ0-9 skos:prefLabel "usage thérapeutique (Qualificatif)"@fr, "therapeutic use (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-THHNVC7V-3 skos:prefLabel "synthèse chimique (Qualificatif)"@fr, "chemical synthesis (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-M63HSDM7-1 skos:prefLabel "antagonists & inhibitors (Qualifier)"@en, "antagonistes et inhibiteurs (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-S0CS1X5R-5 skos:prefLabel "immunology (Qualifier)"@en, "immunologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-HQRFT0C6-B skos:prefLabel "isolement et purification (Qualificatif)"@fr, "isolation & purification (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T2TS0S41-N skos:prefLabel "ultrastructure (Qualifier)"@en, "ultrastructure (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NB0XHT3S-N skos:prefLabel "adverse effects (Qualifier)"@en, "effets indésirables (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-W6SQV79N-S skos:prefLabel "classification (Qualifier)"@en, "classification (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CB30NGKB-3 skos:prefLabel "economics (Qualifier)"@en, "économie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr: a skos:ConceptScheme . jvr:-SBNWSM1T-R skos:prefLabel "history (Qualifier)"@en, "histoire (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-CJXMKG5Q-F skos:prefLabel "deficiency (Qualifier)"@en, "déficit (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-D0F21513-5 skos:prefLabel "chemistry (Qualifier)"@en, "composition chimique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-R3QWLHRG-V skos:prefLabel "standards (Qualifier)"@en, "normes (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NHL3D2X0-S skos:prefLabel "sang (Qualificatif)"@fr, "blood (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-T9HQD7ST-J skos:prefLabel "ressources et distribution (Qualificatif)"@fr, "supply & distribution (Qualifier)"@en ; a mesh:Qualifier, skos:Concept . jvr:-N2WP45CN-V skos:prefLabel "drug effects (Qualifier)"@en, "effets des médicaments et des substances chimiques (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-NKM836P1-M skos:prefLabel "pharmacology (Qualifier)"@en, "pharmacologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WK5F724J-1 skos:prefLabel "pharmacokinetics (Qualifier)"@en, "pharmacocinétique (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept . jvr:-WZF2ZR3L-B skos:prefLabel "physiology (Qualifier)"@en, "physiologie (Qualificatif)"@fr ; a mesh:Qualifier, skos:Concept .