@prefix c0x: <http://data.loterre.fr/ark:/67375/C0X> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc11: <http://purl.org/dc/elements/1.1/> .

c0x:-VB19Q0GR-W
  skos:prefLabel "protease inhibitor"@en, "inhibiteur de protéase"@fr ;
  a skos:Concept ;
  skos:narrower c0x:-W85D2LV8-N .

c0x:-W85D2LV8-N
  skos:definition "Aujourd'hui le ritonavir est principalement prescrit non pas pour son action antivirale mais pour sa capacité à inhiber les enzymes qui éliminent d'autres inhibiteurs de la protéase, en qualité de booster. (Wikipédia)"@fr, "Ritonavir was originally developed as an inhibitor of HIV protease, one of a family of pseudo-C2-symmetric small molecule inhibitors. Ritonavir is now rarely used for its own antiviral activity but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular enzyme, in intestines, liver, and elsewhere, that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). (Wikipedia)"@en ;
  a skos:Concept ;
  skos:broader c0x:-VB19Q0GR-W ;
  skos:inScheme c0x: ;
  skos:prefLabel "ritonavir"@en, "ritonavir"@fr ;
  dc11:creator "Patricia Fener" ;
  skos:exactMatch <https://fr.wikipedia.org/wiki/Ritonavir>, <https://en.wikipedia.org/wiki/Ritonavir> .

c0x: a skos:ConceptScheme .