@prefix c0x: <http://data.loterre.fr/ark:/67375/C0X> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc11: <http://purl.org/dc/elements/1.1/> .

c0x:-VBHG595P-9
  skos:broader c0x:-ZS5G50N5-R ;
  dc11:creator "Patricia Fener" ;
  skos:inScheme c0x: ;
  skos:prefLabel "Janus kinase 1"@en, "Janus kinase 1"@fr ;
  skos:exactMatch <https://en.wikipedia.org/wiki/Janus_kinase_1>, <https://fr.wikipedia.org/wiki/Janus_kinase_1> ;
  skos:altLabel "JAK1"@en, "JAK1"@fr ;
  a skos:Concept ;
  skos:definition "La janus kinase 1 est une tyrosine kinase, membre de la famille des janus kinases. Son gène est le JAK1 situ sur le chromosome 1 humain. (Wikipédia)"@fr, "JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. (Wikipedia)"@en .

c0x:-ZS5G50N5-R
  skos:prefLabel "Janus kinase"@en, "Janus kinase"@fr ;
  a skos:Concept ;
  skos:narrower c0x:-VBHG595P-9 .

c0x: a skos:ConceptScheme .