@prefix c0x: <http://data.loterre.fr/ark:/67375/C0X> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix dc11: <http://purl.org/dc/elements/1.1/> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

c0x:-PVRCTDRG-V
  a skos:Concept ;
  skos:inScheme c0x: ;
  skos:altLabel "mémoire immunitaire innée"@fr, "mémoire immunitaire entraînée"@fr, "innate immune memory"@en ;
  skos:broader c0x:-JVR20L88-F ;
  skos:prefLabel "immunité entraînée"@fr, "trained immunity"@en ;
  dc11:creator "Patricia Fener" ;
  skos:definition "The concept of trained immunity describes the long-term functional reprogramming of innate immune cells, which is evoked by exogenous or endogenous insults and which leads to an altered response towards a second challenge after the return to a non-activated state. The secondary response to the subsequent non-specific stimulus can be altered in such a way that the cells respond more or less strongly than to the primary response, conferring context-adjusted and time-adjusted responses. Netea, M. G., et al. (2020). \"Defining trained immunity and its role in health and disease.\" Nat Rev Immunol 20(6): 375-388."@en ;
  dc:modified "2020-11-01"^^xsd:date .

c0x: a skos:ConceptScheme .
c0x:-JVR20L88-F
  skos:prefLabel "immunity"@en, "immunité"@fr ;
  a skos:Concept ;
  skos:narrower c0x:-PVRCTDRG-V .