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Concept information

Chemical Phenomena > Biochemical Phenomena > Up-Regulation
Genetic Phenomena > Gene Expression Regulation > Up-Regulation
Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacological Phenomena > Up-Regulation

Terme préférentiel

Up-Regulation  

Type

  • mesh:Descriptor

Définition

  • A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. A positive regulatory process that increases ligand-receptor interactions. Increase in receptor binding after ligand exposure can result from receptor activation, aggregation, increase in half-life, and/or an increase in gene expression that leads to de novo receptor synthesis.

Concept générique

Concepts associés

Synonyme(s)

  • Upregulation
  • Up-Regulation (Physiology)

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-ZVSL5SBQ-B

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RDF/XML TURTLE JSON-LD Date de création 26/05/1989, dernière modification le 17/06/2016