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Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Immunologic > Integrins > Receptors, Leukocyte-Adhesion

Terme préférentiel

Receptors, Leukocyte-Adhesion  

Type

  • mesh:Descriptor

Définition

  • Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.

Concept générique

Concepts spécifiques

Concepts associés

Synonyme(s)

  • Leu-CAM Receptor Family
  • Leukocyte-Adhesion Receptor
  • Leukocyte-Adhesion Receptor Family
  • Leukocyte-Adhesion Receptors

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-ZSC3HTJN-M

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RDF/XML TURTLE JSON-LD Date de création 07/07/1989, dernière modification le 09/07/2003