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Concept information

Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Deoxycytidine > Zalcitabine
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Ribonucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Ribonucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Pyrimidine Nucleosides > Cytidine > Deoxycytidine > Zalcitabine
Nucleic Acids, Nucleotides, and Nucleosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zalcitabine
... > Carbohydrates > Glycosides > Nucleosides > Deoxyribonucleosides > Dideoxynucleosides > Zalcitabine

Terme préférentiel

Zalcitabine  

Type

  • mesh:Descriptor

Définition

  • A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

Concept générique

Concepts spécifiques

Synonyme(s)

  • 2',3'-Dideoxycytidine
  • 6L3XT8CB3I
  • 7481-89-2 (Zalcitabine)
  • Cytidine, 2',3'-dideoxy-
  • ddC (Antiviral)
  • Dideoxycytidine

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

  • Zalcitabine

    français

  • 6L3XT8CB3I
  • 7481-89-2 (Zalcitabine)
  • Cytidine, 2',3'-dideoxy-
  • Didésoxycytidine

URI

http://data.loterre.fr/ark:/67375/JVR-Z0HF807D-C

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RDF/XML TURTLE JSON-LD Date de création 14/07/1989, dernière modification le 24/05/2017