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Concept information

Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Protein Disorders > Protein S Deficiency
Hemic and Lymphatic Diseases > Hematologic Diseases > Thrombophilia > Protein S Deficiency
Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Coagulation Disorders > Protein S Deficiency

Terme préférentiel

Protein S Deficiency  

Type

  • mesh:Descriptor

Définition

  • An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

Concept générique

Synonyme(s)

  • Deficiency, Protein S
  • Hereditary Thrombophilia Due To Protein S Deficiency

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-NMGF1DN9-P

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RDF/XML TURTLE JSON-LD Date de création 16/04/1994, dernière modification le 08/07/2013