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Concept information

Immune System Phenomena > Complement Activation > Complement Pathway, Classical

Terme préférentiel

Complement Pathway, Classical  

Type

  • mesh:Descriptor

Définition

  • Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

Concept générique

Synonyme(s)

  • Classical Complement Activation Pathway
  • Classical Complement Pathway
  • Complement Activation Pathway, Classical

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-MSTCHM92-4

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RDF/XML TURTLE JSON-LD Date de création 02/12/1977, dernière modification le 23/06/2016