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Concept information

... > Eukaryota > Animals > Animal Population Groups > Animals, Laboratory > Animals, Inbred Strains > Mice, Inbred Strains > Mice, Inbred CFTR
... > Eukaryota > Animals > Chordata > Vertebrates > Mammals > Eutheria > Rodentia > Muridae > Murinae > Mice > Mice, Inbred Strains > Mice, Inbred CFTR

Terme préférentiel

Mice, Inbred CFTR  

Type

  • mesh:Descriptor

Définition

  • A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.

Concept générique

Concepts associés

Synonyme(s)

  • Mice, CFTR
  • Mouse, CFTR
  • Mouse, Inbred CFTR

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-MBKGFT6D-M

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RDF/XML TURTLE JSON-LD Date de création 03/06/1993, dernière modification le 02/09/2020