Concept information
Terme préférentiel
Debrisoquin
Type
-
mesh:Descriptor
Définition
- An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Concept générique
Synonyme(s)
- 1131-64-2 (Debrisoquin)
- 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
- Debrisoquine
- X31CDK040E
Qualificatif(s) autorisé(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Action(s) pharmacologique(s)
Traductions
-
français
-
1131-64-2 (Debrisoquin)
-
2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
-
X31CDK040E
URI
http://data.loterre.fr/ark:/67375/JVR-LRJ3FXGW-C
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