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Concept information

Chemical Phenomena > Biochemical Phenomena > Down-Regulation
Genetic Phenomena > Gene Expression Regulation > Down-Regulation
Physiological Phenomena > Pharmacological and Toxicological Phenomena > Pharmacological Phenomena > Down-Regulation

Terme préférentiel

Down-Regulation  

Type

  • mesh:Descriptor

Définition

  • A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. A negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the internalization of ligand-receptor complex, an increase in receptor degradation, and/or a decrease in gene expression resulting in a decrease in receptor biosynthesis.

Concept générique

Concepts associés

Synonyme(s)

  • Downregulation
  • Down-Regulation (Physiology)

Qualificatif(s) autorisé(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-L45DZ3W7-K

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RDF/XML TURTLE JSON-LD Date de création 26/05/1989, dernière modification le 17/06/2016