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Concept information

Terme préférentiel

Properdin  

Type

  • mesh:Descriptor

Définition

  • A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

Synonyme(s)

  • 11016-39-0
  • Complement Factor P
  • Complement factor P

Action(s) pharmacologique(s)

Traductions

  • français

  • 11016-39-0
  • Complement factor P
  • Facteur P du complément

URI

http://data.loterre.fr/ark:/67375/JVR-KH5FR65V-X

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RDF/XML TURTLE JSON-LD Date de création 01/01/1999, dernière modification le 23/06/2015