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Concept information

Carbohydrates > Glycosides > Cardiac Glycosides
Polycyclic Compounds > Fused-Ring Compounds > Steroids > Cardanolides > Cardiac Glycosides

Terme préférentiel

Cardiac Glycosides  

Type

  • mesh:Descriptor

Définition

  • Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.

Concept générique

Concepts spécifiques

Synonyme(s)

  • Cardiac Glycoside
  • Cardiotonic Steroid
  • Cardiotonic Steroids

Qualificatif(s) autorisé(s)

Action(s) pharmacologique(s)

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-C1ZWPH34-6

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RDF/XML TURTLE JSON-LD Date de création 01/01/1999, dernière modification le 27/05/2020