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Concept information

Terme préférentiel

MutL Proteins  

Type

  • mesh:Descriptor

Définition

  • DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.

Traductions

URI

http://data.loterre.fr/ark:/67375/JVR-C10GB86R-3

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RDF/XML TURTLE JSON-LD Date de création 08/07/2016, dernière modification le 26/02/2016