: MeSH: Genes, erbA

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Genes, erbA

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Genes related to the erbA DNA sequence that was first isolated from the avian erythroblastosis virus (ERYTHROBLASTOSIS VIRUS, AVIAN), v-erbA. In cells, erbA genes encode thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA genes have been identified: erbA-alpha located at 17q21; and erbA-beta located at 3p24. Truncations at the N- and C-terminals of erbA result in products resembling v-erbA. Truncations affect hormone responsiveness but not DNA binding capacity. Viral oncogenes that are homologues of erbA1 (THRA) gene which encodes thyroid hormone receptor alpha. v-erbA Oncogenes potentiate the transforming ability of other oncogenes such as v-erbB by inhibiting spontaneous differentiation of already transformed cells.

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