: MeSH: MutL Protein Homolog 1

Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > MutL Proteins > MutL Protein Homolog 1

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > MutL Proteins > MutL Protein Homolog 1

... > Hydrolases > Acid Anhydride Hydrolases > Adenosine Triphosphatases > MutL Proteins > MutL Protein Homolog 1

MutL Protein Homolog 1

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Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.

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