: MeSH: Liver X Receptors

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Liver X Receptors

Amino Acids, Peptides, and Proteins > Proteins > Receptors, Cytoplasmic and Nuclear > Liver X Receptors

Liver X Receptors

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Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. They have important functions in regulating cholesterol homeostasis, ENERGY METABOLISM; INFLAMMATION; and the immune response. A liver X receptor that is ubiquitously expressed. Loss of LXR-beta function is associated with an increase in the expression of UNCOUPLING PROTEIN 1 as well as OBESITY. A liver X receptor that is expressed primarily by cells in the liver and other metabolically-active tissues.

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