: MeSH: Soluble Guanylyl Cyclase

Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Guanylate Cyclase > Soluble Guanylyl Cyclase

Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Guanylate Cyclase > Soluble Guanylyl Cyclase

... > Enzymes > Lyases > Phosphorus-Oxygen Lyases > Guanylate Cyclase > Soluble Guanylyl Cyclase

Soluble Guanylyl Cyclase

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A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.

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