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... > Enzymes and Coenzymes > Enzymes > Transferases > Glycosyltransferases > Pentosyltransferases > ADP Ribose Transferases

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ADP Ribose Transferases  

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Tipo

  • mesh:Descriptor

Definición

  • Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains. Enzymes that catalyze the transfer of one ADP-ribose moiety from NAD+ to an amino acid residue in specific protein substrates. This reaction is catalyzed by prokaryotic and eukaryotic enzymes. Mono-ADP-ribosylation is a mechanism of action common to several bacterial toxins. An enzyme that catalyzes the transfer of the ADP-ribose moiety from NAD+ or NADP+ to specific protein substrates with arginine, arginine-type compounds, agmatine, or guanidine as acceptors. This mono-ADP-ribosylation reaction is the mechanism of action common to several bacterial toxins affecting profound changes in cellular metabolism, such as activation of adenylate cyclase, regulation of protein synthesis at the level of elongation factor 2, and ion transport across biological membranes. An enzyme that catalyze the transfer of ADP-RIBOSE from NAD+ to an amino acid residue in a specific protein substrate. This reaction is catalyzed by both mono(ADP-ribose) transferases as well as POLY(ADP-RIBOSE) POLYMERASES. When the term NAD+ ADP-Ribosyltransferase refers to EC 2.4.2.30 it is referring to POLY(ADP-RIBOSE) POLYMERASES.

Concepto genérico

Conceptos específicos

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Etiquetas alternativas

  • 81457-93-4 (CAS RN)
  • ADP Ribose Transferase
  • ADP-Ribosyltransferase
  • ADPRT
  • ADPRTs
  • ART Transferase
  • ART Transferases
  • ARTase
  • ARTases

En otras lenguas

URI

http://data.loterre.fr/ark:/67375/JVR-J72RJJQG-0

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