: MeSH: Prion Proteins

... > Proteins > Glycoproteins > Membrane Glycoproteins > GPI-Linked Proteins > Prion Proteins

... > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > GPI-Linked Proteins > Prion Proteins

... > Proteins > Membrane Proteins > Membrane Glycoproteins > GPI-Linked Proteins > Prion Proteins

... > Proteins > Membrane Proteins > Lipid-Linked Proteins > GPI-Linked Proteins > Prion Proteins

Amino Acids, Peptides, and Proteins > Proteins > Prions > Prion Proteins

Prion Proteins

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Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU. An overlapping open reading frame within the PRNP gene that encodes a protein which is smaller and structurally unrelated to major prion protein.

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