: MeSH: Eosinophilia-Myalgia Syndrome

Musculoskeletal Diseases > Muscular Diseases > Eosinophilia-Myalgia Syndrome

Nervous System Diseases > Neuromuscular Diseases > Muscular Diseases > Eosinophilia-Myalgia Syndrome

Hemic and Lymphatic Diseases > Hematologic Diseases > Leukocyte Disorders > Eosinophilia > Eosinophilia-Myalgia Syndrome

Eosinophilia-Myalgia Syndrome

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A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)

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