Concept information
Preferred term
Genes, erbB-1
Type
-
mesh:Descriptor
Definition
- The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Broader concept
Synonym(s)
- erbB-1 Genes
- Genes, erbB1
Allowable Qualifier(s)
In other languages
-
French
-
Gène erbB-1
-
Gènes erbB1
URI
http://data.loterre.fr/ark:/67375/JVR-WHHNH96P-C
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