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Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > RNA-Binding Proteins > RNA Recognition Motif Proteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > RNA-Binding Proteins > RNA Recognition Motif Proteins > Heterogeneous-Nuclear Ribonucleoproteins > RNA-Binding Protein FUS

Preferred term

RNA-Binding Protein FUS  

Type

  • mesh:Descriptor

Definition

  • A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

Broader concept

Synonym(s)

  • Fusion Protein in Myxoid Liposarcoma
  • FUS Protein
  • FUS RNA-Binding Protein
  • hnRNP P2
  • POMp75 Protein
  • TLS Protein
  • Translocated in Liposarcoma Protein

Allowable Qualifier(s)

In other languages

  • Protéine FUS de liaison à l'ARN

    French

  • hnRNP-P2
  • Protéine de fusion du liposarcome myxoïde
  • Protéine FUS
  • Protéine FUS liant l'ARN
  • Protéine POMp75
  • Protéine TLS

URI

http://data.loterre.fr/ark:/67375/JVR-VTWRTDGZ-V

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RDF/XML TURTLE JSON-LD Created 7/3/02, last modified 4/15/15