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Concept information

Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > Valosin Containing Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > Adenosine Triphosphatases > ATPases Associated with Diverse Cellular Activities > Valosin Containing Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > AAA Proteins > ATPases Associated with Diverse Cellular Activities > Valosin Containing Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > AAA Proteins > ATPases Associated with Diverse Cellular Activities > Valosin Containing Protein

Preferred term

Valosin Containing Protein  

Type

  • mesh:Descriptor

Definition

  • A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

Broader concept

Synonym(s)

  • CDC48 Protein
  • Cell Cycle Protein CDC48
  • Cell Cycle Protein CDC48p
  • p97 Valosin-Containing Protein
  • Valosin-Containing Protein
  • Valosine-Containing Protein

Allowable Qualifier(s)

In other languages

  • Protéine contenant la valosine

    French

  • Protéine CDC48
  • Protéine contenant de la valosine
  • Protéine du cycle cellulaire CDC48
  • Protéine du cycle cellulaire CDC48p
  • Protéine p97 contenant la valosine

URI

http://data.loterre.fr/ark:/67375/JVR-SSF3R6BN-S

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/2/17