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... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > CARD Signaling Adaptor Proteins > Apoptotic Protease-Activating Factor 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > CARD Signaling Adaptor Proteins > Apoptotic Protease-Activating Factor 1
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > CARD Signaling Adaptor Proteins > Apoptotic Protease-Activating Factor 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > CARD Signaling Adaptor Proteins > Apoptotic Protease-Activating Factor 1
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > CARD Signaling Adaptor Proteins > Apoptotic Protease-Activating Factor 1

Preferred term

Apoptotic Protease-Activating Factor 1  

Type

  • mesh:Descriptor

Definition

  • A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.

Broader concept

Synonym(s)

  • Apaf-1 Protease-Activating Factor
  • Apoptotic Peptidase Activating Factor 1

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-SNBGGWV9-6

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RDF/XML TURTLE JSON-LD Created 7/5/06, last modified 4/15/16