Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

  • Help
align
annotate
download

Concept information

... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > Complement Factor I
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > Complement Factor I
... > Amino Acids, Peptides, and Proteins > Proteins > Blood Proteins > Immunoproteins > Complement System Proteins > Complement Inactivator Proteins > Complement C3b Inactivator Proteins > Complement Factor I

Preferred term

Complement Factor I  

Type

  • mesh:Descriptor

Definition

  • A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

Broader concept

Synonym(s)

  • C3b-C4b Inactivator
  • C3b Inactivator
  • C4b-C3b-INA
  • C4bC3bINA
  • Complement 3b-Complement 4b Inactivator
  • Complement C4b-C3b Inactivator

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • Facteur I du complément

    French

  • Inactivateur C3b-C4b
  • Inactivateur des fragments C3b-C4b du complément
  • Inactivateur du C3b

URI

http://data.loterre.fr/ark:/67375/JVR-SL6DCZDS-1

Download this concept:

RDF/XML TURTLE JSON-LD Created 5/7/92, last modified 7/6/09