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Concept information

Preferred term

BRCA1 Protein  

Type

  • mesh:Descriptor

Definition

  • The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)

Synonym(s)

  • BRCA1 Gene Product
  • Breast Cancer 1 Gene Product
  • Breast Cancer 1 Protein
  • Breast Cancer Type 1 Susceptibility Protein
  • Ring Finger Protein 53

In other languages

  • French

  • Produit du gène BRCA1
  • Produit du gène-1 du cancer du sein
  • Protéine-1 du cancer du sein

URI

http://data.loterre.fr/ark:/67375/JVR-RVD05M67-L

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