Concept information
Preferred term
Nomifensine
Type
-
mesh:Descriptor
Definition
- An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Broader concept
Synonym(s)
- 1LGS5JRP31
- 24526-64-5 (Nomifensine)
- 32795-47-4 (maleate (1:1))
- 76S8CUH5MR
- 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
- Linamiphen
- Nomifensin
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- agonists (Qualifier)
- analogs & derivatives (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- economics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- urine (Qualifier)
Pharmacological Action(s)
In other languages
-
French
-
1LGS5JRP31
-
24526-64-5 (Nomifensine)
-
32795-47-4 (maleate (1:1))
-
76S8CUH5MR
-
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
URI
http://data.loterre.fr/ark:/67375/JVR-QV54589P-M
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