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Macromolecular Substances > Multiprotein Complexes > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Enzymes and Coenzymes > Enzymes > Transferases > One-Carbon Group Transferases > Methyltransferases > Protein Methyltransferases > Histone Methyltransferases > Histone-Lysine N-Methyltransferase > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein

Preferred term

Enhancer of Zeste Homolog 2 Protein  

Type

  • mesh:Descriptor

Definition

  • A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

Broader concept

Synonym(s)

  • Enhancer of Zeste Homolog 2
  • Histone-Lysine N-Methyltransferase EZH2
  • Lysine N-Methyltransferase-6

Allowable Qualifier(s)

In other languages

  • Protéine-2 homologue de l'activateur de Zeste

    French

  • Histone-lysine N-methyltransferase EZH2
  • Histone-lysine N-méthyltransférase EZH2
  • Homologue-2 de l'activateur de Zeste
  • Lysine N-methyltransferase-6
  • Lysine N-méthyltransferase-6

URI

http://data.loterre.fr/ark:/67375/JVR-PC3K05SQ-G

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 6/19/18