: MeSH: Thyroid Nuclear Factor 1

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Thyroid Nuclear Factor 1

Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Homeodomain Proteins > Thyroid Nuclear Factor 1

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Thyroid Nuclear Factor 1

Thyroid Nuclear Factor 1

A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

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