Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

align
annotate
download

Concept information

... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Dipeptidyl-Peptidases and Tripeptidyl-Peptidases > Tripeptidyl-Peptidase 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Tripeptidyl-Peptidase 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Exopeptidases > Aminopeptidases > Tripeptidyl-Peptidase 1

Preferred term

Tripeptidyl-Peptidase 1  

Type

  • mesh:Descriptor

Definition

  • Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.

Broader concept

Synonym(s)

  • CLN2 Protein
  • TPP1 Protein
  • Tripeptidyl Aminopeptidase I
  • Tripeptidyl Peptidase I
  • Tripeptidyl-Peptidase I
  • Tripeptidyl Protease I

Allowable Qualifier(s)

In other languages

  • Tripeptidyl-peptidase-1

    French

  • Protéine CLN2
  • Protéine TPP1
  • Tripeptidyl aminopeptidase I
  • Tripeptidyl protease I
  • Tripeptidyl-peptidase I

URI

http://data.loterre.fr/ark:/67375/JVR-NZCLV6XQ-1

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/9/21, last modified 4/29/22