Concept information
Preferred term
Antibody-Dependent Cell Cytotoxicity
Type
-
mesh:Descriptor
Definition
- The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Broader concept
Narrower concepts
Synonym(s)
- ADCC
- Cell Cytoxicity, Antibody-Dependent
- Cytotoxicity, Antibody-Dependent Cell
Allowable Qualifier(s)
In other languages
-
French
-
CCDA
-
Cytotoxicité à médiation cellulaire dépendante des Ac
-
Cytotoxicité anticorps dépendante
-
Cytotoxicité cellulaire dépendante des anticorps
URI
http://data.loterre.fr/ark:/67375/JVR-NKG64S5Q-H
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