Concept information
Preferred term
Nucleic Acid Denaturation
Type
-
mesh:Descriptor
Definition
- Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Broader concept
Allowable Qualifier(s)
In other languages
URI
http://data.loterre.fr/ark:/67375/JVR-N0M5B5TV-N
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