Concept information
Preferred term
Complement Pathway, Classical
Type
-
mesh:Descriptor
Definition
- Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Broader concept
Synonym(s)
- Classical Complement Activation Pathway
- Classical Complement Pathway
- Complement Activation Pathway, Classical
Allowable Qualifier(s)
In other languages
-
French
-
Voie classique du complément
URI
http://data.loterre.fr/ark:/67375/JVR-MSTCHM92-4
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