Concept information
Preferred term
Homogentisate 1,2-Dioxygenase
Type
-
mesh:Descriptor
Definition
- A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Broader concept
Synonym(s)
- 9029-49-6 (CRN)
- Homogentisate Dioxygenase
- Homogentisate Oxidase
- Homogentisate Oxygenase
- Homogentisic Acid Oxidase
Allowable Qualifier(s)
- administration & dosage (Qualifier)
- adverse effects (Qualifier)
- analysis (Qualifier)
- antagonists & inhibitors (Qualifier)
- biosynthesis (Qualifier)
- blood (Qualifier)
- cerebrospinal fluid (Qualifier)
- chemical synthesis (Qualifier)
- chemistry (Qualifier)
- classification (Qualifier)
- deficiency (Qualifier)
- drug effects (Qualifier)
- economics (Qualifier)
- genetics (Qualifier)
- history (Qualifier)
- immunology (Qualifier)
- isolation & purification (Qualifier)
- metabolism (Qualifier)
- pharmacokinetics (Qualifier)
- pharmacology (Qualifier)
- physiology (Qualifier)
- poisoning (Qualifier)
- radiation effects (Qualifier)
- standards (Qualifier)
- supply & distribution (Qualifier)
- therapeutic use (Qualifier)
- toxicity (Qualifier)
- ultrastructure (Qualifier)
- urine (Qualifier)
In other languages
-
French
-
9029-49-6 (CRN)
-
Acide homogentisique-oxydase
-
Homogentisate dioxygénase
-
Homogentisate oxydase
-
Homogentisate oxygenase
-
Oxydase de l'acide homogentisique
-
Oxydase homogentisique
URI
http://data.loterre.fr/ark:/67375/JVR-LVVM5Z4F-H
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