Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

  • Help
align
annotate
download

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Karyopherins > alpha Karyopherins
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Transport Proteins > Nucleocytoplasmic Transport Proteins > Karyopherins > alpha Karyopherins
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Membrane Transport Proteins > Nucleocytoplasmic Transport Proteins > Karyopherins > alpha Karyopherins

Preferred term

alpha Karyopherins  

Type

  • mesh:Descriptor

Definition

  • Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.

Broader concept

Related concepts

Synonym(s)

  • Importin-alpha
  • Karyopherin alpha
  • NLS-Binding Protein
  • NLSBP
  • NLS Receptor
  • Nuclear Localization Sequence Receptor
  • Nuclear Localization Signal-Binding Protein

Allowable Qualifier(s)

In other languages

  • Cariophérines alpha

    French

  • Cariophérine alpha
  • Kariophérines alpha
  • Protéine de liaison au signal de localisation nucléaire
  • Protéine de liaison du signal de localisation nucléaire
  • Récepteur NLS (Nuclear Localization Signal)

URI

http://data.loterre.fr/ark:/67375/JVR-LV9T29HV-4

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/25/01, last modified 7/12/05