Skip to main content

Medical Subject Headings (thesaurus)

Search from vocabulary

  • Help
align
annotate
download

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > F-Box-WD Repeat-Containing Protein 7
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > F-Box Proteins > F-Box-WD Repeat-Containing Protein 7
... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > SKP Cullin F-Box Protein Ligases > F-Box-WD Repeat-Containing Protein 7

Preferred term

F-Box-WD Repeat-Containing Protein 7  

Type

  • mesh:Descriptor

Definition

  • A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Broader concept

Synonym(s)

  • F-Box and WD-40 Domain-Containing Protein 7
  • FBXW7 Protein

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-KQ1PJH0D-S

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 2/27/17