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... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptor Protein-Tyrosine Kinases > Receptor, IGF Type 1
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Receptor, IGF Type 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Receptor, IGF Type 1
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein-Tyrosine Kinases > Receptor Protein-Tyrosine Kinases > Receptor, IGF Type 1
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Receptors, Peptide > Receptors, Growth Factor > Receptors, Somatomedin > Receptor, IGF Type 1

Preferred term

Receptor, IGF Type 1  

Type

  • mesh:Descriptor

Definition

  • A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.

Broader concept

Related concepts

Synonym(s)

  • IGF-1 Receptor
  • IGF-I Receptor
  • IGF Type 1 Receptor
  • Insulin-Like-Growth Factor I Receptor
  • Receptor, IGF-I
  • Receptor, Insulin-Like Growth Factor I
  • Receptor, Insulin-Like Growth Factor Type 1
  • Receptors, IGF-1
  • Receptors, Insulin-Like-Growth Factor I

Allowable Qualifier(s)

In other languages

  • Récepteur IGF de type 1

    French

  • Récepteur du facteur de croissance 1 analogue à l'insuline
  • Récepteur IGF-1
  • Récepteurs IGF de type 1

URI

http://data.loterre.fr/ark:/67375/JVR-JMDLC90N-C

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RDF/XML TURTLE JSON-LD Created 5/29/92, last modified 5/21/21