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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Basic Helix-Loop-Helix Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Basic Helix-Loop-Helix Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Basic-Leucine Zipper Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Basic-Leucine Zipper Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein

Preferred term

N-Myc Proto-Oncogene Protein  

Type

  • mesh:Descriptor

Definition

  • A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

Broader concept

Synonym(s)

  • BHLHE37 Protein
  • Class E Basic Helix-Loop-Helix Protein 37
  • MYCN Protein
  • N-Myc Protein
  • NMYC Protein

Allowable Qualifier(s)

In other languages

  • Protéine du proto-oncogène N-Myc

    French

  • Protéine BHLHE37
  • Protéine MYCN
  • Protéine N-Myc
  • Protéine NMYC
  • Protéine-37 à motifs basiques hélice-boucle-hélice de classe E

URI

http://data.loterre.fr/ark:/67375/JVR-G9NQFLHZ-0

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 4/15/16