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... > Chemical Actions and Uses > Pharmacologic Actions > Molecular Mechanisms of Pharmacological Action > Enzyme Inhibitors > Protease Inhibitors > Serine Proteinase Inhibitors > Serpins > Antithrombin Proteins > Hirudins
Amino Acids, Peptides, and Proteins > Peptides > Serpins > Antithrombin Proteins > Hirudins
Amino Acids, Peptides, and Proteins > Proteins > Serpins > Antithrombin Proteins > Hirudins

Preferred term

Hirudins  

Type

  • mesh:Descriptor

Definition

  • Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN. A 65-residue polypeptide from LEECHES.

Broader concept

Related concepts

Synonym(s)

  • 8001-27-2

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-FHTQRVK0-V

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