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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 1

Preferred term

High-Temperature Requirement A Serine Peptidase 1  

Type

  • mesh:Descriptor

Definition

  • A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

Broader concept

Related concepts

Synonym(s)

  • Serine Protease HTRA1

Allowable Qualifier(s)

In other languages

  • High-temperature requirement A serine peptidase 1

    French

  • Sérine peptidase A1 requise à haute température
  • Sérine peptidase A1 requise à température élevée
  • Sérine protéase A1 requise à haute température
  • Sérine protéase A1 requise à température élevée
  • Serine protease HTRA1
  • Sérine protéase HTRA1
  • Sérine protéinase A1 requise à haute température
  • Sérine protéinase A1 requise à température élevée

URI

http://data.loterre.fr/ark:/67375/JVR-F03JB7QL-V

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 6/1/17