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Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines > Pyridinium Compounds > 1-Methyl-4-phenylpyridinium

Preferred term

1-Methyl-4-phenylpyridinium  

Type

  • mesh:Descriptor

Definition

  • An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

Broader concept

Related concepts

Synonym(s)

  • 1-Methyl-4-phenylpyridine
  • 1-Methyl-4-phenylpyridinium Ion
  • 39794-99-5 (chloride)
  • 48134-75-4 (1-Methyl-4-phenylpyridinium)
  • Cyperquat
  • MRP3DNB9K9
  • N-Methyl-4-phenylpyridine
  • N-Methyl-4-phenylpyridinium
  • Pyridinium, 1-methyl-4-phenyl-
  • R865A5OY8J

Allowable Qualifier(s)

Pharmacological Action(s)

In other languages

  • 1-Méthyl-4-phényl-pyridinium

    French

  • 1-Méthyl-4-phénylpyridinium
  • 39794-99-5 (chloride)
  • 48134-75-4 (1-Methyl-4-phenylpyridinium)
  • MRP3DNB9K9
  • Pyridinium, 1-methyl-4-phenyl-
  • R865A5OY8J

URI

http://data.loterre.fr/ark:/67375/JVR-C8FKRNNN-9

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RDF/XML TURTLE JSON-LD Created 5/16/89, last modified 5/27/16