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Concept information

Cell Physiological Phenomena > Cell Death > Regulated Cell Death > Apoptosis

Preferred term

Apoptosis  

Type

  • mesh:Descriptor

Definition

  • A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis that is triggered via cell stress and mitochondrial damage. Apoptosis that is triggered via CELL SURFACE RECEPTORS such as TUMOR NECROSIS FACTOR RECEPTORS and DEATH DOMAIN RECEPTORS. Physiological forms of regulated cell death that occur during growth and development and tissue turnover.

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Related concepts

Synonym(s)

  • Classical Apoptosis
  • Classic Apoptosis
  • Programmed Cell Death, Type I

Allowable Qualifier(s)

In other languages

  • Apoptose

    French

  • MCP de type I
  • Mort cellulaire apoptotique
  • Mort cellulaire programmée de type 1
  • Mort cellulaire programmée de type I

URI

http://data.loterre.fr/ark:/67375/JVR-BXVMNJSN-S

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RDF/XML TURTLE JSON-LD Created 5/7/92, last modified 6/30/21