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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Secondary > Amino Acid Motifs > Immunoreceptor Tyrosine-Based Activation Motif

Preferred term

Immunoreceptor Tyrosine-Based Activation Motif  

Type

  • mesh:Descriptor

Definition

  • A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

Broader concept

Synonym(s)

  • Immune Receptor Tyrosine-Based Activation Motif
  • Immuno-Receptor Tyrosine-Based Activation Motif

Allowable Qualifier(s)

In other languages

URI

http://data.loterre.fr/ark:/67375/JVR-BPP66K9M-6

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RDF/XML TURTLE JSON-LD Created 7/3/12, last modified 7/5/16