Concept information
Terme préférentiel
trained immunity
Définition
- The concept of trained immunity describes the long-term functional reprogramming of innate immune cells, which is evoked by exogenous or endogenous insults and which leads to an altered response towards a second challenge after the return to a non-activated state. The secondary response to the subsequent non-specific stimulus can be altered in such a way that the cells respond more or less strongly than to the primary response, conferring context-adjusted and time-adjusted responses. Netea, M. G., et al. (2020). "Defining trained immunity and its role in health and disease." Nat Rev Immunol 20(6): 375-388.
Concept générique
Synonyme(s)
- innate immune memory
Créateur
- Patricia Fener
Traductions
-
français
-
mémoire immunitaire entraînée
-
mémoire immunitaire innée
URI
http://data.loterre.fr/ark:/67375/C0X-PVRCTDRG-V
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