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Concept information

... > virus > viral tropism > host cell > host cell protein > host cell protease > type II transmembrane serine protease
virus-host interaction > protein marker > host cell protein > host cell protease > type II transmembrane serine protease

Terme préférentiel

type II transmembrane serine protease  

Définition

  • Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. (Wikipedia)
  • Viral entry requires not only binding to the ACE2 receptor but also priming of the virus’s spike (S) protein by the transmembrane protease serine 2 (TMPRSS2) by cleavage of the S proteins at the S1/S2 and S2 sites. Baughn, L. B., et al. (2020). "Targeting TMPRSS2 in SARS-CoV-2 Infection." Mayo Clin Proc 95(9): 1989-1999.

Concept générique

Concepts associés

Synonyme(s)

  • membrane-anchored serine protease, TMpRSS2
  • membrane-bound serine protease TMPRSS2
  • serine protease
  • serine protease TMpRSS2
  • TMpRSS2 protease
  • transmembrane protease serine 2
  • transmembrane serine protease 2
  • transmembrane serine protease TMpRSS2

Créateur

  • Patricia Fener

Traductions

URI

http://data.loterre.fr/ark:/67375/C0X-NF3PGZJB-5

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RDF/XML TURTLE JSON-LD Dernière modification le 05/01/2021