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Covid-19 (thesaurus)

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Concept information

... > virus > respiratory virus > Coronavirinae > viral protein > structural protein > spike protein > S1 subunit > receptor binding domain > receptor-binding motif
... > virus > RNA virus > positive-strand RNA virus > Nidovirales > Coronaviridae > Coronavirinae > viral protein > structural protein > spike protein > S1 subunit > receptor binding domain > receptor-binding motif
... > virus-host interaction > protein marker > viral protein > structural protein > spike protein > S1 subunit > receptor binding domain > receptor-binding motif
... > clinical research > candidate treatment > therapeutic target > viral protein > structural protein > spike protein > S1 subunit > receptor binding domain > receptor-binding motif

Preferred term

receptor-binding motif  

Definition

  • The receptor-binding motif (RBM) is the main functional motif in the receptor-binding domain (RBD) and is composed of two regions (region 1 and region 2) that form the interface between the S protein and human receptor angiotensin-converting enzyme 2 (hACE2). Yi, C., et al. (2020). "Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies." Cellular & Molecular Immunology 17(6): 621-630.

Broader concept

Synonym(s)

  • RBM
  • receptor binding motif

Creator

  • Patricia Fener

In other languages

URI

http://data.loterre.fr/ark:/67375/C0X-P94XHT1N-H

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RDF/XML TURTLE JSON-LD Created 12/22/20, last modified 1/1/21