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... > clinical research > vaccine > technology platform > adjuvant > non-aluminum adjuvant > toll-like receptor agonist > toll-like receptor 3 agonist > Polyinosinic-polycytidylic acid
... > virus > respiratory virus > Coronavirinae > transmission > human to human transmission > prevention > vaccine > technology platform > adjuvant > non-aluminum adjuvant > toll-like receptor agonist > toll-like receptor 3 agonist > Polyinosinic-polycytidylic acid
... > virus > RNA virus > positive-strand RNA virus > Nidovirales > Coronaviridae > Coronavirinae > transmission > human to human transmission > prevention > vaccine > technology platform > adjuvant > non-aluminum adjuvant > toll-like receptor agonist > toll-like receptor 3 agonist > Polyinosinic-polycytidylic acid

Preferred term

Polyinosinic-polycytidylic acid  

Definition

  • Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed at the endosomal membrane of B-cells, macrophages and dendritic cells. Poly I:C is structurally similar to double-stranded RNA, which is present in some viruses and is a "natural" stimulant of TLR3. Thus, Poly I:C can be considered a synthetic analog of double-stranded RNA and is a common tool for scientific research on the immune system. (Wikipédia)

Broader concept

Synonym(s)

  • Poly I:C
  • Polyinosinic:polycytidylic acid

Creator

  • Patricia Fener

In other languages

URI

http://data.loterre.fr/ark:/67375/C0X-C20JKM3D-5

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